The significance of wireframes in web design lies in their role as foundational blueprints for website structure and functionality. They provide a clear visual representation of layout and navigation, enabling designers to establish the site’s framework before actual development begins. Wireframes facilitate collaboration among stakeholders by allowing for early feedback on design concepts and usability. Additionally, they help identify potential design issues and ensure alignment with project goals. By focusing on user experience and interaction, wireframes are essential in creating intuitive and effective web interfaces.