Using standardized protocols in networking is significant as they promote interoperability and consistent communication between different devices and systems. These protocols define rules for data exchange, formatting, and error handling, making it easier for diverse technologies to work together. For instance, adhering to standards like TCP/IP or HTTP ensures that systems can connect and communicate efficiently, reducing the risk of data loss and enhancing overall network performance. This standardization is crucial for scalability and compatibility in today's complex network environments.