The significance of using frameworks in software development lies in their ability to provide a structured environment for building applications. Frameworks offer reusable code, standardized procedures, and best practices that streamline the development process, reducing the likelihood of errors. They enhance efficiency by promoting code modularity, making it easier for developers to collaborate and maintain applications. Additionally, frameworks often come with built-in tools and libraries that expedite the implementation of complex functionalities, allowing teams to focus more on innovation rather than repetitive tasks.