The significance of natural language processing (NLP) in user interactions lies in its ability to enable computers to understand, interpret, and respond to human language in a meaningful way. NLP enhances communication between users and machines, making interactions more intuitive and user-friendly. Through applications like chatbots, virtual assistants, and sentiment analysis, NLP allows for personalized user experiences and faster responses. As AI technology advances, NLP continues to play a vital role in bridging the gap between human communication and machine understanding, transforming how we engage with digital systems.