The significance of data centers in cloud computing lies in their role as the backbone of cloud infrastructure. These facilities house the servers, storage systems, and networking components necessary for delivering cloud services to users. By utilizing multiple data centers, providers can ensure high availability, redundancy, and scalability, accommodating diverse computing needs. They also facilitate efficient resource management, allowing for the on-demand provisioning of computational power. Data centers contribute to the overall performance and reliability of cloud services, significantly impacting how businesses and individuals access and utilize technology resources.