The significance of compliance in managing IT infrastructure lies in ensuring adherence to legal, regulatory, and organizational standards. Compliance frameworks, like GDPR or HIPAA, mandate specific data handling practices, which organizations must follow to protect sensitive information. Effective compliance management helps organizations mitigate risks associated with data breaches, legal penalties, and reputational damage. Additionally, maintaining compliance fosters trust among customers and stakeholders, establishing a solid foundation for long-term relationships. By integrating compliance into IT infrastructure, organizations can enhance their security posture and overall operational effectiveness.