The acronym WYSIWYG stands for "What You See Is What You Get," and it refers to a type of web design interface that allows users to create content in a form that resembles its final output. With WYSIWYG editors, designers can visually manipulate the layout and formatting of a webpage without needing to write extensive code. This approach simplifies the web design process, making it accessible to those without programming expertise, while still delivering a professional appearance.