The acronym E2E stands for end-to-end, referring to encryption processes that secure data from its origin to destination. E2E encryption ensures that only the communicating users can read the messages, protecting the data against interception and unauthorized access. This method is critical for preserving privacy in communications, as it safeguards information across various platforms and protects against potential data breaches. The significance of end-to-end encryption lies in its ability to provide a higher level of security, thus fostering trust among users in digital communications.