Challenges in maintaining IT infrastructure in organizations include keeping up with rapid technological advancements, ensuring system security, and managing data integrity. Regular updates and patches are necessary to protect against vulnerabilities, which can strain resources. Additionally, organizations face difficulties in scaling their infrastructure to meet growing demands, often leading to increased costs. Staff training and skills development are also crucial, as a knowledgeable workforce is essential to effectively manage complex systems and troubleshoot issues, ensuring optimal performance and service delivery.