The primary role of the human liver in metabolism is the regulation and synthesis of various biochemical processes essential for homeostasis. The liver metabolizes nutrients, detoxifies harmful substances, stores vitamins and minerals, and produces critical proteins such as albumin and clotting factors. It plays a central role in glucose metabolism, converting excess glucose into glycogen for storage and releasing it back into the bloodstream as needed. Moreover, the liver is involved in the metabolism of fats and proteins, coordinating energy production and maintaining overall metabolic balance in the body.