The Bill of Rights is significant in the United States Constitution as it enumerates and protects the fundamental rights of individuals, ensuring essential liberties such as freedom of speech, religion, and assembly. Ratified in 1791, it serves as a critical safeguard against government overreach, affirming the principle that certain rights are inherent and cannot be infringed upon. The Bill of Rights has significantly influenced legal interpretations and human rights standards in American society, reinforcing democratic values.