The main antagonist in the epic of Gilgamesh is Humbaba, the monstrous guardian of the Cedar Forest. Gilgamesh and his friend Enkidu confront Humbaba to demonstrate their strength and seek glory. Humbaba represents the challenges and fears that heroes must face, as well as the guardian of the world’s resources. Gilgamesh's encounter with Humbaba profoundly influences the adventure, encapsulating themes of heroism, friendship, and the struggle against nature.