One significant story that highlights the conflict between man and nature in mythology is the tale of Prometheus. He defied the gods by stealing fire and giving it to humanity, symbolizing enlightenment and knowledge. However, this act of rebellion angered Zeus, who punished Prometheus by having him bound to a rock where an eagle would eat his liver daily. This myth illustrates the struggle between human aspiration and the harsh consequences of challenging divine order, emphasizing themes of sacrifice, creativity, and nature retaliating against hubris.