The primary focus of the Myth of Sisyphus is the concept of absurdism and the human struggle against the inevitability of death. Sisyphus, condemned by the gods to eternally roll a boulder uphill only to watch it roll back down, embodies the futility of life and the pursuit of meaning. The myth illustrates the human condition, emphasizing that despite the struggle, one can find personal significance and rebellion in the act of enduring. Sisyphus's plight encourages individuals to embrace their struggles and the absurdity of their existence rather than succumb to despair.