The mythological significance of the cosmic serpent is prevalent in various cultures, often representing creation, renewal, and duality. In Mesoamerican cultures, serpents like the Quetzalcoatl symbolize the intertwining of earth and sky. In Hindu mythology, the serpent Ananta upholds the universe. These serpents embody the connection between the cosmos, deities, and humanity, emphasizing the cyclical nature of life and the interconnectedness of all beings within the universe.