The main theme of the Epic of Gilgamesh revolves around the quest for immortality and the profound exploration of human existence. Through Gilgamesh's journey, the text delves into themes of friendship, loss, and the inevitability of death, reflecting on what it means to be human. Gilgamesh's search for eternal life ultimately leads to the understanding that legacy, wisdom, and the impact on others can transcend mortality. This theme resonates universally, inviting readers to contemplate their own lives and the connections that give meaning to existence.