The significance of the Bill of Rights in the United States lies in its role as a critical safeguard for individual liberties and rights. Ratified in 1791 as the first ten amendments to the Constitution, it aimed to address Anti-Federalist concerns regarding the potential for government overreach and tyranny. The Bill of Rights enumerates essential freedoms, such as speech, religion, assembly, and the right to bear arms. It serves to protect citizens from government infringement on these rights, establishing a framework for American democracy and reinforcing the importance of civil liberties in the nation's governance.