The significance of the Alamo in American history lies in its role as a symbol of resistance and sacrifice during the Texas Revolution. In 1836, a group of Texian defenders, including famous figures like James Bowie and Davy Crockett, held the Alamo in San Antonio against a much larger Mexican force led by General Santa Anna for 13 days. Although the defenders were ultimately defeated, their bravery inspired other Texians to rally for independence from Mexico. The phrase "Remember the Alamo!" became a rallying cry for Texas patriots, and the battle is now a key event in the narrative of American struggle for freedom.