The major impact of the **Fall of Constantinople** in **1453** was its profound reshaping of **European** and **Middle Eastern** dynamics. The Ottoman Empire's conquest marked the end of the Byzantine Empire and facilitated increased Ottoman influence over trade routes. This shift prompted European powers to seek alternative trade routes, birthing the **Age of Exploration**. Furthermore, the city's fall signaled a cultural and intellectual migration, as scholars fled to Europe, preserving classical knowledge, which contributed to the **Renaissance**. The event also heightened tensions between Christianity and Islam, leading to further conflict in the region.