A major consequence of the Great Schism of the Catholic Church in 1054 was the formal split between Eastern Orthodoxy and Roman Catholicism. This division arose from longstanding theological, cultural, and political differences, including disputes over papal authority and the insertion of the "Filioque" clause into the Nicene Creed. The schism led to the establishment of two distinct branches of Christianity, with the Eastern Orthodox Church centered in Constantinople and the Roman Catholic Church based in Rome. This separation had profound impacts on the religious landscape of Europe, contributing to distinct religious practices, doctrines, and cultural developments that continue today.