The establishment of the first American colonies in North America was driven by a mix of economic, religious, and political motivations. In the early 1600s, England sought new markets and resources to bolster trade, encouraging the settlement of ventures like Jamestown in 1607. Additionally, Puritans and Pilgrims seeking religious freedom embarked on the Mayflower in 1620, leading to the founding of Plymouth Colony. The combination of these factors—economic pursuits and the desire for religious autonomy—set the stage for the gradual growth of numerous colonies along the Eastern seaboard, ultimately contributing to the foundation of the United States.