The role of antioxidants in preventing chronic diseases is crucial as they combat oxidative stress in the body. Oxidative stress occurs when there is an imbalance between free radicals and antioxidants, potentially leading to conditions such as heart disease, cancer, and diabetes. Antioxidants, found in a variety of fruits and vegetables, help neutralize harmful free radicals, thereby reducing inflammation and cellular damage. Some important antioxidants include vitamin C, vitamin E, and selenium. Incorporating a diet rich in antioxidants may enhance overall health and contribute to longevity, making them essential in chronic disease prevention.