Chronic stress negatively impacts physical health by triggering prolonged release of cortisol, which can lead to various conditions such as hypertension, heart disease, and weakened immune function. This ongoing stress disrupts the body's homeostasis and can also contribute to mental health issues. Additionally, stress may lead to unhealthy coping mechanisms like overeating, smoking, or substance abuse, further exacerbating health problems. Managing stress through relaxation techniques, exercise, and social support is crucial in mitigating these risks and promoting overall well-being.