A sprain and a strain are different injuries affecting connective tissues. A sprain involves the stretching or tearing of ligaments, the bands connecting bones at joints, often resulting from sudden twists or impacts. In contrast, a strain refers to the overstretching or tearing of muscles or tendons, commonly occurring from overexertion. Effective treatment varies, with sprains often requiring rest, ice, compression, and elevation (RICE), while strains may necessitate physical rehabilitation.