Glucagon and insulin play pivotal roles in energy metabolism by regulating blood sugar levels. Insulin facilitates the uptake of glucose into cells for energy production or storage as fat, while glucagon serves as a counterregulatory hormone promoting the release of glucose from liver stores. Together, they maintain homeostasis in blood sugar levels, enabling the body to respond effectively to varying energy demands. Proper function of these hormones is essential for maintaining metabolic health and preventing conditions like diabetes.