Best practices for safe weight loss involve a gradual and sustainable approach. This includes setting realistic goals, such as losing 1-2 pounds per week, which can promote long-term results. A balanced diet rich in whole foods, combined with regular physical activity, is essential. Portion control and mindful eating can help reduce caloric intake without feeling deprived. Additionally, tracking food and exercise habits can increase accountability. It's beneficial to seek support from healthcare professionals to ensure nutritional needs are met and to tailor a program that suits individual circumstances.