Muscle fatigue influences overall performance during workouts by decreasing strength and stamina. When muscles become fatigued, their ability to contract and generate force diminishes, leading to reduced performance levels. This can result in incomplete sets, poor form, and increased risk of injury. Furthermore, fatigue limits concentration and mental focus, further hindering output. It is essential for athletes to recognize fatigue signs, allowing them to adapt training intensity and focus on recovery strategies to optimize performance and avoid burnout.