Strategies for the General Science paper in UPSC Mains should focus on understanding fundamental concepts rather than rote memorization. Aspirants should prioritize core topics such as physics, chemistry, and biology and use NCERT textbooks for clarity. Engaging with recent developments in science and technology and their impact on society is also crucial. Regular practice through previous years' question papers can help identify frequently asked questions and exam patterns. Creating concise notes for quick revisions can aid in retaining vast information and boost confidence while tackling the General Science paper.