Candidates can tackle multiple-choice questions in the UPSC Prelims by employing strategic approaches. First, they should utilize the process of elimination to narrow down options, thereby increasing the likelihood of selecting the correct answer. Time management is crucial; candidates must allocate time wisely to avoid rushing. Additionally, practicing mock tests can help familiarize candidates with the question format and improve decision-making speed. Emotional regulation is also important; staying calm and focused can greatly enhance performance under the pressure of examination conditions.