The significance of the General Studies papers in the UPSC Mains Examination lies in their role in assessing a candidate's understanding of diverse critical issues affecting society and governance. These papers cover a wide array of topics like geography, Indian history, and current events, ensuring candidates have a well-rounded knowledge base. They also test analytical skills and the ability to synthesize information, making them crucial for identifying candidates' readiness for administrative roles and understanding the socio-political landscape.