The significance of General Studies papers in the UPSC Mains Examination lies in their comprehensive assessment of an aspirant's knowledge and understanding of various subjects relevant to governance and society. These papers cover topics such as Indian history, politics, economy, environment, science and technology, ensuring candidates are well-rounded. They also test analytical skills and current affairs awareness, which are crucial for a career in public services. Scoring well in these papers is vital for candidates aiming for success in the overall examination.