Aspirants can enable resilience against setbacks during UPSC preparation by adopting a growth mindset, recognizing that challenges are opportunities for learning. Setting realistic and achievable goals can help mitigate feelings of overwhelm. Regular self-reflection on one's progress and strategies allows candidates to adjust their approaches as needed. Establishing a support system of peers or mentors also provides motivation and guidance. Engaging in physical activities like yoga or sports can help in managing stress. Lastly, maintaining a balanced lifestyle with adequate rest and recreational activities is essential for mental well-being.