Candidates should approach general science topics for the UPSC examination by focusing on core concepts and their real-world applications. A structured strategy involves categorizing subjects such as physics, chemistry, and biology into manageable sections. It's important to utilize NCERT textbooks as foundational resources, supplemented with reference books for deeper insights. Regular revision and taking practice tests can enhance retention and confidence. Additionally, staying updated on recent scientific advancements and their implications can help aspirants relate broader themes to contemporary issues, ensuring a well-rounded grasp for both preliminary and mains assessments.