The iconic queen of Egypt known for her relationships with powerful Roman leaders is Cleopatra. As the last active ruler of the Ptolemaic Kingdom, her alliances with Julius Caesar and Mark Antony were not only personal but also political strategies to secure Egypt's power against Rome's growing influence. Cleopatra's intelligence, charisma, and political acumen made her a significant figure in history. Her reign was marked by efforts to maintain Egypt’s independence amid the tumultuous Roman expansion, securing her legacy as a complex and powerful leader.