The first woman to run a Fortune 500 company was Katharine Graham, who led the Washington Post Company. Her tenure as CEO began in 1972 and marked a significant breakthrough in corporate leadership for women. Graham's vision transformed the company, especially during the pivotal period of Watergate, where her decisions were crucial in maintaining journalistic integrity. Under her leadership, the Washington Post became a trusted news source. Graham's legacy continues to inspire women aspiring to leadership roles in business and journalism, emphasizing the importance of resilience and courage in overcoming barriers.