The main contributions of Marie Curie to chemistry and physics include her pioneering research on radioactivity and the discovery of the elements polonium and radium. Curie's work laid the groundwork for advancements in both fields, earning her the distinction of being the first woman to win a Nobel Prize and the only individual to receive Nobel Prizes in two different sciences. Her research not only advanced scientific understanding but also had practical applications in medicine and radiation therapy. Curie's legacy is celebrated for breaking barriers for women in science.