F. Scott Fitzgerald's literary themes were significantly impacted by his personal relationships. His tumultuous marriage to Zelda Sayre greatly influenced his exploration of love, ambition, and the struggles of the Jazz Age. The complexities of their relationship, marked by passion and conflict, became a recurring motif in his works, particularly in "The Great Gatsby." Fitzgerald's experiences with wealth and excess reflected his insights into the American Dream. His reflections on infidelity and existential despair revealed a sense of longing and disillusionment, making his characters both relatable and tragic figures in a rapidly changing society.