The major event that influenced the works of Pablo Picasso was the Spanish Civil War, particularly reflected in his painting "Guernica." This tumultuous period profoundly affected him artistically and personally, leading to themes of suffering and chaos in his work. "Guernica" serves as a powerful political statement against the horrors of war and is considered one of his most significant contributions to contemporary art. The emotional weight of the conflict inspired Picasso to explore human tragedy and resilience in ways that resonated deeply with audiences.