Mahalia Jackson faced multiple setbacks in her musical career, particularly related to her struggles against racism and the expectations of the music industry. Despite her extraordinary vocal talent, she encountered difficulties in gaining recognition and opportunities due to the racial prejudices of her time. Jackson also fought for creative control over her music, leading to conflicts with record labels that sought to commercialize her style. However, her unwavering dedication to gospel music and her role in the Civil Rights Movement helped her navigate these challenges, ultimately solidifying her status as a legendary figure in American music history.