Leonardo da Vinci's interdisciplinary approach to art and science was motivated by a profound curiosity and a drive to explore nature. His background in the Renaissance period allowed him to merge various fields, including painting, anatomy, and engineering, fostering an innovative mindset. Da Vinci believed in the interconnectedness of all knowledge, leading him to conduct detailed studies of the human body and the natural world, which informed his artwork. This synthesis of artistic vision and scientific inquiry allowed him to create masterpieces like the "Mona Lisa" and "The Last Supper," while also advancing inventions that influenced future scientific thought.