Bill Gates was motivated to focus on global health initiatives post-Microsoft by witnessing the profound impact of disease and the need for equitable healthcare. His experiences in philanthropy, particularly through the Bill & Melinda Gates Foundation, highlighted the disparities in health outcomes worldwide. Through extensive research and collaboration with health organizations, Gates aimed to combat diseases like malaria and polio, believing in the power of innovation and funding to improve health systems. His commitment to global health reflects a desire to create sustainable change and enhance quality of life for the most vulnerable populations.