Florence Nightingale faced numerous obstacles in her nursing career, primarily due to prevailing societal norms and her gender. During the 19th century, nursing was not regarded as a respectable profession for women, hindering her opportunities and professional recognition. Nightingale also encountered substantial resistance when implementing her evidence-based practices in healthcare, as traditional methods dominated at the time. Despite these challenges, she persevered, establishing nursing as a profession and founding modern nursing education. Her pioneering work during the Crimean War emphasized sanitation and proper care, revolutionizing healthcare practices and significantly improving patient outcomes.