The major historical figure known for her work in advocating for the rights of Native Americans is Wilma Mankiller. As the first female chief of the Cherokee Nation, Mankiller dedicated her life to improving the living conditions and rights of Indigenous peoples. Her leadership focused on self-determination and empowering Native communities through programs in health, education, and economic development. Mankiller’s efforts were pivotal in advocating for the recognition of tribal sovereignty and laying the groundwork for future Indigenous leadership within the United States.