Georgia O'Keeffe was inspired by the natural beauty of the American Southwest. Her iconic paintings of flowers, bones, and landscapes reflect her deep connection to the environment and vibrant colors she observed. The vast desert and cultural elements of New Mexico profoundly influenced her artistic vision, leading her to develop a unique style characterized by abstraction and minimalism. O'Keeffe's work challenged conventional representations of femininity and nature, positioning her as a pioneer in modern art. Her explorations of form and color opened new avenues for artistic expression, influencing many artists who followed.