Mary Shelley's writings significantly shaped the science fiction genre, particularly with her novel Frankenstein. Often considered the first true science fiction work, it explores themes of creation, responsibility, and the ethical implications of scientific advancement. Shelley's blend of Gothic horror and philosophical inquiry challenged contemporary notions of progress, highlighting the potential consequences of human hubris. Her exploration of the relationship between creator and creation continues to resonate, serving as a cautionary tale about unchecked ambition and the moral dilemmas posed by scientific exploration.