The defining relationships that informed the artistic journey of Andy Warhol include his connections with influential figures in the Pop Art movement. Warhol's collaboration with artists, musicians, and celebrities, such as Lou Reed and David Bowie, shaped his creative output and inspired themes of fame and commercialism in his work. His relationship with his family, particularly his immigrant background, also influenced his identity as an artist. Warhol's social interactions and cultural engagements forged a unique perspective, making him a pivotal figure in contemporary art history.