Jane Addams confronted numerous challenges in her social reform work, primarily focusing on issues such as poverty, racial inequality, and labor rights. As a founder of Hull House in Chicago, she faced resistance from those opposed to her vision of social justice and community support. She struggled with limited funding and resources while trying to provide educational and social services to immigrants and the poor. Additionally, Addams dealt with societal prejudices against women in the public sphere, advocating for women's rights and the importance of civic engagement. Her dedication laid the groundwork for modern social work.