Florence Nightingale faced numerous challenges as a pioneer in nursing, particularly in expanding healthcare reform. During the Crimean War, she encountered a lack of resources, inadequate sanitation, and high mortality rates, requiring her to advocate fiercely for change. She developed the principle of evidence-based practice, often clashing with prevailing medical norms. Additionally, Nightingale navigated significant gender bias in the medical field, striving to elevate nursing as a respected profession. Despite these barriers, her relentless pursuit of improvement and her establishment of nursing schools revolutionized healthcare, making her a lasting figure in medical history.